Ultrasound contrast agents

Ultrasound contrast agents are used in echocardiography to enhance the contrast in cardiac perfusion images. These agents consist of micron-sized gas bubbles coated with a polymer or lipid coating. The interaction between these microbubbles and high-frequency ultrasound is studied by acoustical and optical means. A high-speed imaging system with a frame rate of upto 25 million frames per second is used to visualize bubble oscillations, non-linear responses and in some cases bubble collapse. The latter process is exploited for diagnostic and therapeutic use of a new class of contrast agents.

Ultra high-speed imaging website.

Info: Michel Versluis

Researchers: Erik Gelderblom, Michel Versluis, Nico de Jong, Detlef Lohse.
Collaborators: Erasmus MC, Benjamin Dollet (U Rennes), Peter Frinking (Bracco Research, Geneva), Glenn Ticker (Point Biomedical), Sascha Hilgenfeldt (Northwestern University, USA), Philippe Marmottant (CNRS, Grenoble)
Embedding: MIRA, JMBC
Sponsors: FOM, ICIN

Publications

Pulse subtraction time delay imaging method for ultrasound contrast agent detection
J.M. Borsboom, A. Bouakaz, and N. de Jong
UFFC 56, 1151–1158 (2009)BibTeΧ
Contrast agent response to chirp reversal: simulations optical observations, and acoustical verification ,
A. Novell, S. van der Meer, M. Versluis, N. de Jong, and A. Bouakaz
UFFC 56, 1199–1206 (2009)BibTeΧ
Nonspherical Oscillations of Ultrasound Contrast Agent Microbubbles
B. Dollet, S. van der Meer, V. Garbin, N. de Jong, D. Lohse, and M. Versluis
Ultrasound Med. Biol. 34, 1465–1473 (2008)BibTeΧ
Acoustic characterization of single ultrasound contrast agent microbubbles
J. Sijl, E. Gaud, P.J.A. Frinking, M. Arditi, N. de Jong, D. Lohse, and M. Versluis
J. Acoust. Soc. Am. 124, 4091–4097 (2008)BibTeΧ
Microbubble spectroscopy of ultrasound contrast agents
S. van der Meer, B. Dollet, M.M. Voormolen, C.T. Chin, A. Bouakaz, N. de Jong, M. Versluis, and D. Lohse
J. Acoust. Soc. Am. 121, 648–656 (2007)BibTeΧ
Changes in microbubble dynamics near a boundary revealed by combined optical micromanipulation and high-speed imaging
V. Garbin, D. Cojoc, E. Ferrari, E. Di Fabrizio, M. Overvelde, S. van der Meer, N. de Jong, D. Lohse, and M. Versluis
Appl. Phys. Lett. 90, 114103 (2007)BibTeΧ
A model for large amplitude oscillations of coated bubbles accounting for buckling and rupture
P. Marmottant, S. van der Meer, M. Emmer, M. Versluis, N. de Jong, S. Hilgenfeldt, and D. Lohse
J. Acoust. Soc. Am. 118, 3499–3505 (2005)BibTeΧ
High-speed optical observations of contrast agent destruction
A. Bouakaz, M. Versluis, and N. de Jong
Ultrasound Med. Biol. 31, 391–399 (2005)BibTeΧ
High-speed photography during ultrasound illustrates potential therapeutic applications of microbubbles
M. Postema, A. van Wamel, F.J. ten Cate, and N. de Jong
Med. Phys. 32, 3707–3711 (2005)BibTeΧ
Optical observations of acoustical radiation force effects on individual air bubbles
P. Palanchon, P. Tortoli, A. Bouakaz, M. Versluis, and N. de Jong
UFFC 52, 104–110 (2005)BibTeΧ
Harmonic chirp imaging method for ultrasound contrast agent
J.M. Borsboom, C.T. Chin, A. Bouakaz, M. Versluis, and N. de Jong
UFFC 52, 241–249 (2005)BibTeΧ
Ultrasound-induced gas release from contrast agent microbubbles
M. Postema, A. Bouakaz, M. Versluis, and N. de Jong
UFFC 52, 1035–1041 (2005)BibTeΧ
A new ultrasonic transducer for improved contrast nonlinear imaging
A. Bouakaz, F.J. ten Cate, and N. de Jong
Phys. Med. Biol. 49, 3515 (2004)BibTeΧ
Ultrasound-induced encapsulated microbubble phenomena
M. Postema, A. van Wamel, C.T. Lancée, and N. de Jong
Ultrasound Med. Biol. 30, 827–840 (2004)BibTeΧ
Emboli detection using a new transducer design
P. Palanchon, A. Bouakaz, J. Klein, and N. de Jong
Ultrasound Med. Biol. 30, 123–126 (2004)BibTeΧ
Ultrasound-induced microbubble coalescence
M. Postema, P. Marmottant, C.T. Lancée, S. Hilgenfeldt, and N. de Jong
Ultrasound Med. Biol. 30, 1337–1344 (2004)BibTeΧ
Micromanipulation of endothelial cells: Ultrasound-microbubble-cell interaction
A. van Wamel, A. Bouakaz, M. Versluis, and N. de Jong
Ultrasound Med. Biol. 30, 1255–1258 (2004)BibTeΧ
Contrast harmonic transesophageal echocardiography: A feasibility study
A. Bouakaz, B.J. Krenning, E. Biagini, T. Galema, F.J. ten Cate, and N. de Jong
Ultrasound Med. Biol. 30, 877–883 (2004)BibTeΧ
Noninvasive microbubble-based pressure measurements: a simulation study
M. Postema, A. Bouakaz, and N. de Jong
Ultrasonics 42, 759–762 (2004)BibTeΧ
Feasibility of 3D harmonic contrast imaging
M.M. Voormolen, A. Bouakaz, B.J. Krenning, C.T. Lancée, F.J. ten Cate, and N. de Jong
Ultrasonics 42, 739–743 (2004)BibTeΧ
Experimental evaluation of a non-linear coded excitation method for contrast imaging
J.M. Borsboom, C.T. Chin, and N. de Jong
Ultrasonics 42, 671–675 (2004)BibTeΧ
Radionuclide tumour therapy with ultrasound contrast microbubbles
A. van Wamel, A. Bouakaz, B. Bernard, F.J. ten Cate, and N. de Jong
Ultrasonics 42, 903–906 (2004)BibTeΧ
Brandaris 128: A digital 25 million frames per second camera with 128 highly sensitive frames
C.T. Chin, C.T. Lancée, J.M. Borsboom, F. Mastik, M.E. Frijlink, N. de Jong, M. Versluis, and D. Lohse
Rev. Sci. Instrum. 74, 5026–5034 (2003)BibTeΧ
 


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