Physics of Fluids - Publications

Computational Fluid Dynamics for the Prediction of Endograft Thrombosis in the Superficial Femoral Artery

Open Access
Journal of Endovascular Therapy online (2022)

Authors

	Lennart van de Velde
	Erik Groot Jebbink
	Jim Hagmeijer
	Michel Versluis
	M.M.P.J. Reijnen

BibTeΧ

@article{doi:10.1177/15266028221091890,
author = {Lennart van de Velde and Erik Groot Jebbink and Rob Hagmeijer and Michel Versluis and Michel M. P. J. Reijnen},
title ={Computational Fluid Dynamics for the Prediction of Endograft Thrombosis in the Superficial Femoral Artery},
journal = {Journal of Endovascular Therapy},
volume = {0},
number = {0},
pages = {15266028221091890},
year = {0},
doi = {10.1177/15266028221091890},
    note ={PMID: 35466777},

URL = { 
        https://doi.org/10.1177/15266028221091890
    
},
eprint = { 
        https://doi.org/10.1177/15266028221091890
    
}
,
    abstract = { Purpose:Contemporary diagnostic modalities, including contrast-enhanced computed tomography (CTA) and duplex ultrasound, have been insufficiently able to predict endograft thrombosis. This study introduces an implementation of image-based computational fluid dynamics (CFD), by exemplification with 4 patients treated with an endograft for occlusive disease of the superficial femoral artery (SFA). The potential of personalized CFD for predicting endograft thrombosis is investigated.Materials and Methods:Four patients treated with endografts for an occluded SFA were retrospectively included. CFD simulations, based on CTA and duplex ultrasound, were compared for patients with and without endograft thrombosis to investigate potential flow-related causes of endograft thrombosis. Time-averaged wall shear stress (TAWSS) was computed, which highlights areas of prolonged residence times of coagulation factors in the graft.Results:CFD simulations demonstrated normal TAWSS (>0.4 Pa) in the SFA for cases 1 and 2, but low levels of TAWSS (<0.4 Pa) in cases 3 and 4, respectively. Primary patency was achieved in cases 1 and 2 for over 2 year follow-up. Cases 3 and 4 were complicated by recurrent endograft thrombosis.Conclusion:The presence of a low TAWSS was associated with recurrent endograft thrombosis in subjects with otherwise normal anatomic and ultrasound assessment and a good distal run-off. }
}