Physics of Fluids - Publications

Focused ultrasound for opening blood-brain barrier and drug delivery monitored with positron emission tomography

Open Access
Journal of Controlled Release 324, 303 – 316 (2020)

Authors

	W.M. Arif
	P.H. Elsinga
	C. Gasca-Salas
	Michel Versluis
	R. Martínez-Fernández
	R.A.J.O. Dierckx
	R.J.H. Borra
	G. Luurtsema

BibTeΧ

@article{ARIF2020303,
title = "Focused ultrasound for opening blood-brain barrier and drug delivery monitored with positron emission tomography",
journal = "Journal of Controlled Release",
volume = "324",
pages = "303 - 316",
year = "2020",
issn = "0168-3659",
doi = "https://doi.org/10.1016/j.jconrel.2020.05.020",
url = "http://www.sciencedirect.com/science/article/pii/S0168365920302972",
author = "Wejdan M. Arif and Philip H. Elsinga and Carmen Gasca-Salas and Michel Versluis and Raul Martínez-Fernández and Rudi A.J.O. Dierckx and Ronald J.H. Borra and Gert Luurtsema",
keywords = "FUS, Microbubbles, Radiotracers, Blood-brain barrier transporters",
abstract = "Focused ultrasound (FUS) is a minimally-invasive technology used for treatment of many diseases, including diseases related to the colon, uterus, prostate, and brain. Although it has been mainly used for ablative procedures, the ability of FUS to open the blood-brain barrier (BBB) presents a promising new application. However, the mechanism of BBB opening by FUS remains unclear. This review focuses on the use of FUS to open the BBB for enhancing drug delivery and investigating how Positron Emission Tomography (PET) provides insight into the underlying mechanism."
}